Table 1.
Characteristics of Infants with Severe BPD
| Anti-reflux Surgery N=22 |
No Anti-reflux Surgery N=28 |
p-value | |
|---|---|---|---|
| Gestational Age, wks* | 26.7 (23-30) | 26 (23-33) | 0.15 |
|
| |||
| Birth Weight, g* | 725 (510-1390) | 701 (453-1357) | 0.32 |
|
| |||
| Post-Menstrual Age at Admission, wks*§ | 41 (36-48.1) | 38.6 (36-48.6) | 0.14 |
|
| |||
| Respiratory Support on admission, n (%)§ | 0.60 | ||
| Nasal Cannula | 0 (0) | 1 (4) | |
| Non-Invasive Positive Pressure | 7 (32) | 7 (25) | |
| Mechanical Ventilation | 15 (68) | 20 (71) | |
|
| |||
| Airway Malacia, n (%)¶ | 11 (50) | 9 (32) | 0.20 |
|
| |||
| Pulmonary Arterial Hypertension, n (%)Ψ | 18 (82) | 13 (46) | 0.01 |
|
| |||
| Respiratory Support at NICU Discharge | <0.01 | ||
|
| |||
| Room Air | 0 (0) | 4 (14) | |
|
| |||
| Nasal Cannula | 10 (45) | 10 (36) | |
|
| |||
| Tracheostomy | 12 (55) | 6 (21) | |
|
| |||
| Died/Care Withdrawn | 0 (0) | 8 (29) | |
Abbreviations: BPD: bronchopulmonary dysplasia; NICU: neonatal intensive care unit; wks: weeks; g: grams.
Values given as median (inter-quartile range).
Post-menstrual age and respiratory support assessed at 36 weeks post-menstrual age or upon transfer, whichever came first.
Airway malacia included laryngeal, tracheal, and/or bronchial malacia was diagnosed by bronchoscopy or low-dose, high-resolution CT with angiography.
Pulmonary arterial hypertension was diagnosed by cardiac catheterization or echocardiography (defined as an estimated systolic pulmonary artery pressure > 40mmHg in the presence of a measurable tricuspid regurgitant jet velocity or both right ventricular hypertrophy and intraventricular septal flattening).