Table 2. Comparisons of MRI parameters by tissue type between groups.
Control (n=7) | cv | RRMS (n=9) | p-value | difference | |
---|---|---|---|---|---|
| |||||
T1ρ cortical GM (s) | 0.221 ± 0.029 | 13% | 0.225 ± 0.009 | p = 0.695 | 1% |
T1ρ NAWM (s) | 0.172 ± 0.003 | 2% | 0.182 ± 0.011 | p = 0.026 | 6% |
T1ρ T2L (s) | n.a. | n.a. | 0.312 ± 0.029 | n.a. | n.a. |
T2ρ cortical GM (s) | 0.092 ± 0.009 | 10% | 0.097 ± 0.012a | p = 0.396 | 5% |
T2ρ NAWM (s) | 0.084 ± 0.003 | 4% | 0.087 ± 0.007a | p = 0.328 | 4% |
T2ρ T2L (s) | n.a. | n.a. | 0.140 ± 0.035a | n.a. | n.a. |
T1sat cortical GM (s) | 1.101 ± 0.055 | 5% | 1.165 ± 0.086 | p = 0.11 | 6% |
T1sat NAWM (s) | 0.630 ± 0.030 | 5% | 0.738 ± 0.059 | p = 0.0006 | 17% |
T1sat T2L (s) | n.a. | n.a. | 1.216 ± 0.358 | n.a. | n.a. |
MTR cortical GM (%) | 17.69 ± 2.02 | 11% | 17.21 ± 2.27 | p = 0.671 | -3% |
MTR NAWM (%) | 29.34 ± 2.74 | 9% | 25.95 ± 3.23 | p = 0.043 | -12% |
MTR T2L (%) | n.a. | n.a. | 16.48 ± 7.06 | n.a. | n.a. |
Values of MRI parameters are shown as mean±sd for different tissue type and subject populations. Inter-subject coefficient of variation (cv=sd/mean) were calculated in healthy control subjects. P-values refer to un-paired 2-sided t-test between MS subjects and healthy control subjects. Differences of MRI parameters between groups (MS minus controls) are also shown. Parameters that show statistically significant differences between groups are displayed in bold.
: n=7 rather than 9.