Table 1.
Pathway associations in four GWAS data sets of cognitively healthy adults(PFDR< 0.05 and the corresponding uncorrected Pnominal are shown).
| Discovery sample (n = 905) | Replication sample (n = 746) | Zurich sample (n = 410) | AgeCoDe sample (n = 763) | |||||
|---|---|---|---|---|---|---|---|---|
| Database | Gene-set | Number of significant genes | Pnominal | PFDR | Pnominal | PFDR | Pnominal | Pnominal |
| GO | Voltage gated cation channel activity | 28 | 9.90E-05 | 3.19E-02* | 9.90E-05 | 1.28E-02* | 2.00E-03 | 1.68E-02 |
| REACTOME | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | 35 | 9.90E-05 | 3.10E-02* | 1.90E-01 | 5.65E-01 | 1.48E-01 | 2.08E-01 |
| GO | Voltage gated channel activity | 28 | 1.00E-04 | 9.10E-02 | 9.90E-05 | 1.85E-02* | 6.20E-03 | 1.11E-02 |
| GO | Metal ion transmembrane transporter activity | 51 | 3.00E-04 | 5.69E-02 | 1.80E-03 | 1.45E-01 | 9.00E-04 | 2.20E-02 |
| KEGG | Arrhythmogenic right ventricular cardiomyopathy | 29 | 7.00E-04 | 7.64E-02 | 5.35E-02 | 4.23E-01 | 2.90E-02 | 2.99E-01 |
| GO | Cation channel activity | 40 | 1.40E-03 | 1.71E-01 | 9.90E-05 | 1.28E-02* | 9.40E-03 | 2.50E-02 |
| GO | Calcium channel activity | 15 | 1.70E-03 | 1.64E-01 | 4.06E-02 | 5.72E-01 | 8.67E-02 | 6.12E-01 |
| REACTOME | Signaling by Rho GTPases | 36 | 2.20E-03 | 1.59E-01 | 2.30E-03 | 1.23E-01 | 1.00E-03 | 3.98E-02 |
| GO | Gated channel activity | 39 | 2.40E-03 | 2.00E-01 | 1.00E-03 | 1.22E-01 | 1.53E-02 | 1.90E-03 |
| GO | Transmembrane receptor protein kinase activity | 21 | 2.50E-03 | 2.09E-01 | 3.95E-01 | 9.11E-01 | 1.79E-02 | 3.01E-01 |
| GO | Ion channel activity | 45 | 2.80E-03 | 2.46E-01 | 7.00E-04 | 9.30E-02 | 5.64E-02 | 2.31E-02 |
| REACTOME | Signaling by robo receptor | 14 | 3.10E-03 | 1.73E-01 | 5.49E-02 | 2.98E-01 | 1.18E-01 | 2.06E-01 |
| KEGG | Dilated cardiomyopathy | 31 | 3.40E-03 | 1.39E-01 | 3.03E-02 | 4.95E-01 | 2.51E-02 | 2.45E-01 |
| GO | Calmodulin binding | 12 | 3.40E-03 | 1.72E-01 | 9.37E-01 | 9.76E-01 | 4.74E-01 | 3.03E-01 |
| KEGG | Adherens junction | 28 | 3.80E-03 | 1.08E-01 | 2.09E-01 | 6.27E-01 | 2.31E-01 | 6.32E-01 |
| REACTOME | Integrin cell surface interactions | 29 | 4.00E-03 | 2.18E-01 | 8.40E-02 | 3.96E-01 | 3.92E-01 | 2.99E-02 |
| GO | Lamellipodium | 12 | 4.00E-03 | 1.83E-01 | 1.99E-01 | 8.58E-01 | 1.06E-01 | 1.86E-01 |
| REACTOME | Regulation of IFNA signaling | 6 | 4.30E-03 | 1.83E-01 | 6.34E-01 | 7.61E-01 | 1.63E-01 | 3.92E-01 |
| REACTOME | Transport of inorganic cations anions and amino acids oligopeptides | 31 | 4.80E-03 | 2.76E-01 | 8.08E-02 | 3.97E-01 | 9.92E-02 | 1.97E-01 |
| REACTOME | Cell surface interactions at the vascular Wall | 29 | 5.00E-03 | 2.73E-01 | 6.33E-01 | 8.10E-01 | 4.16E-01 | 4.06E-02 |
| GO | Cell cortex part | 12 | 5.10E-03 | 1.93E-01 | 1.08E-01 | 6.99E-01 | 1.96E-01 | 1.98E-01 |
| GO | Leading edge | 18 | 6.70E-03 | 2.30E-01 | 3.46E-01 | 9.70E-01 | 3.11E-01 | 1.22E-01 |
| GO | Protein tyrosine kinase activity | 23 | 6.90E-03 | 2.33E-01 | 3.82E-01 | 9.02E-01 | 1.45E-01 | 2.18E-01 |
| GO | Cortical cytoskeleton | 10 | 7.60E-03 | 2.41E-01 | 1.78E-01 | 8.19E-01 | 3.35E-01 | 3.40E-01 |
| REACTOME | L1cam interactions | 28 | 8.60E-03 | 3.08E-01 | 2.33E-02 | 2.25E-01 | 6.30E-03 | 1.80E-03 |
Pnominal: uncorrected values; PFDR: genome-wide corrected values (FDR);
*
Asterisks denote significance after genome-wide correction