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. 2014 Sep 27;18(5):520. doi: 10.1186/s13054-014-0520-2

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© Castellano et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Recovery of hypotension, oligoanuria, and renal function in endotoxemic animals. (A) Endotoxemic pigs developed hypotension after 3 hours of LPS infusion. CPFA treatment restored blood pressure to basal condition. (B) Presence of oligoanuria was a clear sign of LPS-induced AKI. Urinary output was significantly reversed after 6 hours of CPFA treatment. CPFA treatment significantly reduced serum KIM-1 (C) and cystatin C (D) at 6 and 9 hours from LPS infusion.