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. 2014 Sep 27;18(5):520. doi: 10.1186/s13054-014-0520-2

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© Castellano et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of EC dysfunction by CPFA treatment. (A) In endotoxemic animals, the reduced CD31 (red) expression at vascular level (dotted white arrow) was reversed after 6 hours of CPFA treatment (dotted white arrow). The increased number of CD31⁺/α-SMA⁺ cells induced by LPS infusion (white arrows) was significantly hampered in treated pigs (white arrows). (B) Results are expressed as median ± IQR of the numbers of CD31⁺/α-SMA⁺ cells/HPF of at least five independent animals for each group. (C) Comparison of zoomed peritubular capillaries of endotoxemic (white arrow) and treated endotoxemic pigs (white arrow). Magnification, 630×. To-pro 3 was used to counterstain nuclei (blue).