Figure 3.
Schematic model of the cellular absorption and secretion of electrolytes and water in mammalian colon. Examples of ion transport mechanisms were demonstrated in a single enterocyte. Na+/H+ exchangers types 1, 2, and 3 (NHE1/2/3), proteins downregulated in adenoma (DRA), anion exchangers types 1, 2, and 3 (AE1/2/3), aquaporins 3, 4, and 8 (AQP3/4/8), cystic fibrosis transmembrane conductance regulator (CFTR), short-chain fatty acids (SCFA-), KCl cotransporter (KCC1), carbonic anhydrase (CA) [92,94-97] .