Figure 7.

A, Tat increased GI motility in Tat transgenic mice. Tat⁺ mice showed higher upper GI transit rates compared with Tat⁻. GI transit was measured as distance traveled by charcoal meal. Quantitative PCR showing expression of Tat following 1 week of DOX treatment followed by 3 weeks of regular chow diet. B, Tat was expressed in Tat⁺ and absent in Tat⁻ mouse ilea after 3 weeks without DOX. C, Gastric emptying shows no significant difference in stomach stasis rates between Tat⁺ and Tat⁻ mice. D, Cecal water content is significantly higher in Tat⁺ mice than in Tat⁻. E, The number of stool pellets was significantly higher in Tat⁺ than Tat⁻ mice. *p < 0.05 (Student's t test).