Figure 3.
Control of protein expression by PGC-1α. A, Western blot analysis shows that overexpression of PGC-1α in neuroblastoma cells increases the protein expression of PGC-1α, Syt2, Cplx1, and Nefh, which are negligibly expressed in GFP control cells. B, Western blot analysis demonstrates that protein expression of Syt2, Cplx1, and Nefh, but not the non-PGC-1α-dependent gene Cplx2, were significantly decreased in PGC-1α−/− compared with PGC-1α+/+ cortex. Numbers per group are indicated on the bar histogram. **p < 0.005; ***p < 0.0005, one-tailed t tests. Data are presented as mean ± SEM.