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. 2014 Oct 22;34(43):14484–14501. doi: 10.1523/JNEUROSCI.2567-14.2014

Figure 11.

Figure 11.

A1 KO caused an increase in lysosome biogenesis in microglia in vivo. A, Microglia were isolated from adult CX3CR1/GFP+/+ mice as described in Materials and Methods. The GFP-positive cell population was viewed under fluorescence microscopy. Representative pictures are shown. Scale bar, 20 μm. B, C, Cd11b+ microglia were isolated from adult 3XTg-AD/A1+ and 3XTg-AD/A1− mice at (B) 4 months of age (n = 7 mice per genotype) and (C) 12 months of age (n = 8 mice per genotype). Total RNAs were isolated from microglia, and expression levels of lysosome-specific genes were analyzed by qPCR. Values are mean ± SEM. *p < 0.05. ***p < 0.001.