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. Author manuscript; available in PMC: 2014 Oct 22.
Published in final edited form as: Brain Res Mol Brain Res. 2003 Jul 23;115(2):157–161. doi: 10.1016/s0169-328x(03)00204-3

Fig. 1.

Fig. 1

The L-type Ca2+ channel agonist FPL 64176 induces proenkephalin synthesis in primary striatal culture. (A) Proenkephalin gene levels are upregulated by the L-type Ca2+ channel agonist FPL 64176 (20 μM). This upregulation is blocked by the L-type Ca2+ channel antagonist nifedipine (20 μM). (B) The proenkephalin construct pENKAT12, transfected into primary striatal neurons, is induced by FPL 64176 (20 μM). The induction is blocked by nifedipine (20 μM). The construct with a shorter promoter, Δ80, is not induced by FPL 64176. Average fold induction of n=4–7±S.E.M. is shown. *P<0.001.