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. 2014 Sep 29;111(41):14788–14793. doi: 10.1073/pnas.1410419111

Fig. 1.

Fig. 1.

ASCL1 is highly expressed in a subset of NSCLC cell lines. (A) Unsupervised clustering analysis of genome-wide expression analysis performed on 206 lung cell lines including NSCLCs, SCLCs, and normal immortalized HBECs/HSAECs. (B) Known TP53, KRAS, RB1, and EGFR mutations for the putative NE-NSCLC cohort. (C) Log2 expression differences between NE-NSCLC and NSCLC lines plotted against –log10(P value). ASCL1 is noted. A total of 69 genes fall within the cutoff of ± log2 >5.0 and P < 0.001. (D) Supervised clustering of NSCLC cell lines using the 69 most significantly differentially expressed genes. (E) Log10 relative mRNA expression of ASCL1 in lung cancer cell lines measured by qRT-PCR. (F) Protein expression of ASCL1 in lung cancer cell lines. These data were collected from three separate gels.