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. 2014 Sep 25;111(41):14746–14751. doi: 10.1073/pnas.1410630111

Table 1.

Stabilities of Icore fragments compared with kinetic intermediates

Variant Fragment equilibrium denaturation Kinetic burst-phase intermediate (20)
ΔGunf (kcal/mol) munf (kcal·mol−1·M−1) ΔGunf (kcal/mol) munf (kcal·mol−1·M−1)
WT 3.0 ± 0.3 1.16 ± 0.05 3.5 1.2
I53A 1.1* 1.16* 1.7 1.2
I53L 2.7 ± 0.3 1.15 ± 0.06 3.6 1.2
I53V 3.4 ± 0.9 1.2 ± 0.3 4.0 1.2
*

Using an m-value fixed to that of WT.