Fig. 4.

Comparison of cocultures with sulfate reduction (SR)-negative and SR-positive phenotypes. Each point is the average growth rate (A) or yield (B) of three replicates of an evolved coculture (solid squares) or an EPD coculture that was derived from evolved coculture U9 (green), H6 (aqua), or H2 (purple) and had either a SR-positive (+ symbol) or SR-negative (− symbol) phenotype. Error bars indicate 95% confidence intervals calculated from the ANOVA (see SI Methods and Table S5), and asterisks (*) indicate a significant difference between the EPD and the evolved coculture from which it was derived after a sequential Bonferroni correction (P < 0.05 for all 11 tests in the panel).