Table 3.

Hippocampal genes up-regulated with high VitD3 that contain putative VDREs

Gene symbol	Corresponding protein	P value*	RXR-VDR†	Quality score‡
Cntn4	Contactin 4	0.001	AGTTCA TGG AGTTCA	0.74
Ctps2	CTP synthase II	0.003	GGGTCC TAG GGTTCA	0.73
Ppp2r2b	Protein phosphatase 2, regulatory subunit B, beta isoform	0.003	GGGTCA AAG GGTTTA	0.80
Sntb1	Syntrophin, beta-1	0.0002	GGGTCA TCC AGTTCA	0.76
Synj1	Synaptojanin 1	0.0006	GGGTCA TGG GGATCA	0.75
Syt2	Synaptotagmin 2	0.004	GGGTCA AAG GGTCCA	0.73
Tusc3	Tumor suppressor candidate 3	0.001	GGGTCA TTG GGGTCA	0.73

RXR, retinoid-X receptor.

^*P value: Significance of up-regulation from microarray.

^†VDRE consensus sequence from Jaspar motif database: Pu-G-G/T-T-C/G-A-nnn-Pu-G-G/T-G/T-C-A. Underlined T's represent highly conserved nucleotides in the classic consensus VDRE (43).

^‡Sequence quality score according to analysis with Partek Genomics software.