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. 2014 Sep 29;111(41):E4289–E4297. doi: 10.1073/pnas.1409321111

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Fig. 3. — GNRs topically added to collagen I:Matrigel ECM with a spheroid formed by mammary epithelial cells (MCF10A). (A) Copolarized (HH) and cross-polarized (HV) B-mode images of collagen I:Matrigel ECM show strong scattering from GNRs in the ECM and an absence of GNRs in the spheroid (indicated by arrows). (B) M-mode OCT obtained from the central A-line from images in A (only 75 ms of the 1.2 s of data are shown), and the corresponding depth-resolved τ_HH and τ_HV are shown. In regions with diffusing GNRs, τ_HV < τ_HH due to the faster decay mode associated with GNR rotation. In the spheroid, τ_HH ∼ τ_HV with values that are characteristically larger than those from GNRs in the ECM.