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. Author manuscript; available in PMC: 2015 Sep 12.
Published in final edited form as: Semin Immunopathol. 2014 Sep 12;36(5):541–551. doi: 10.1007/s00281-014-0444-6

Table 1.

Characteristics of pathogenic versus nonpathogenic Th17 cells [81]

Nonpathogenic Th17 cells Pathogenic Th17 cells
Cytokine Millieu IL-6, TGF-β1 IL-6, IL-23, TGF-β3
Transcriptional signature (increased expression) CXCL3, IL-22, IL-3, CCL4, GZMB, LRMP, CCL5, CASP1, CSF2, CCL3, TBC21, ICOD, IL-7R, STAT4, LGALS3, LAG3 I6ST, IL1RN, IKZF3, MAF, AHR, IL-9, IL-10