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. 2014 Oct 22;8:117. doi: 10.3389/fnana.2014.00117

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Copyright © 2014 Kelly, Opanashuk and Majewska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dendritic spine density is increased in BPA exposed mice. Confocal images showing representative examples of apical dendrites of layer 5 neurons in somatosensory cortex at low magnification following oil (A) and BPA treatment (C). High magnification images of boxed regions in (A) and (C) showing distribution and qualitative appearance of dendritic spines in oil (B) and BPA treated animals (D). (E) Schematic showing exposure parameters for BPA treatment. (F) Quantitative analysis showing that BPA exposure during the early postnatal period increases dendritic spine density on apical dendrites of layer 5 neurons (solid bar) relative to oil control (clear bar). *p < 0.05. Scale bars: A,C = 200 μm; B,D = 10 μm.