Figure 1. Paclitaxel-induces hyposensitivity to chemical nociception in BALB/c mice.
(A and B) Comparison of BALB/c mice treated with vehicle for paclitaxel (Cremophor EL and ethanol diluted in normal saline on five consecutive days) and naïve mice on paw flinches induced by injection of 5% formalin s.c. on the paw dorsum on day 7 measured using an automated flinch detection system. Cumulative flinches in (A) phase1 (1–9 minutes) and (B) phase 2 (10–40) minutes (n = 8–9 per group). (C, D and E) Effect of treatment with paclitaxel (2 mg/kg on five consecutive days) on paw flinches induced by injection of 5% formalin s.c. on the paw dorsum on day 7 measured using an automated flinch detection system (A) Time course of flinches. Cumulative flinches in (B) phase1 (1–9 minutes) and (C) phase 2 (10–40) minutes (n = 12 per group). * P < 0.05 and * * P < 0.01 compared to vehicle-treated mice.