Figure 2. Coadministration of minocycline with paclitaxel protects against the development of paclitaxel-induced hyposensitivity to chemical nociception.

Effect of coadministration of paclitaxel with minocycline (50 mg/kg on five consecutive days) on paw flinches induced by injection of 5% formalin s.c. on the paw dorsum on day 7 measured using an automated flinch detection system. Cumulative flinches in (A) phase1 (1–9 minutes) and (B) phase 2 (10–40) minutes (n = 7–15 per group). * P < 0.05 and * * P < 0.01 compared to vehicle-treated mice; # P < 0.05 compared to paclitaxel plus vehicle-treated mice.