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. 2014 Oct 22;4:6719. doi: 10.1038/srep06719

Figure 3. Coadministration of minocycline with paclitaxel protects against the development of paclitaxel-induced thermal hyperalgesia.

Figure 3

Effect of administration of paclitaxel 2 mg/kg, minocycline 50 mg/kg or coadministration of paclitaxel with minocycline on five consecutive days on reaction latency times on baseline (PRE) and on day 7 post drug administration (7 dpi) measured using the hot plate test. (n = 8 per group). ** P < 0.01 compared to vehicle-treated mice; ## P < 0.01 compared to paclitaxel plus vehicle-treated mice; and $$ P < 0.01 compared to baseline values.