Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 7;5:5101. doi: 10.1038/ncomms6101

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

After T-cell antigen receptor (TCR) engagement, NAD⁺ promotes naïve CD4⁺ T cell into Th1, Th2 and Th17 cells. NAD⁺ promotes the conversion of Th1-IFN-γ-producing cells into regulatory type 1 cells that co-produce IFN-γ and IL-10 with immunosuppressive properties. NAD⁺ promotes IL-10 and IL-17A cytokines by Th2 cells. NAD⁺ does not affect Th17 cytokine conditions but drives the switch of iTreg into Th17 TGF-β-producing cells. NAD⁺ regulates CD4⁺ T-cell differentiation through Tph1.