Table 2.

FEV₁ AUC_0–3 and trough FEV₁ responses (L) after 12 weeks

Trial/treatment	Change from baseline		Mean difference from tiotropium + placebo
	n	Mean (SE), L	Mean (SE), L	P-value	95% CI
FEV1AUC0–3
ANHELTO 1
Tiotropium + placebo	564	0.196 (0.010)
Olodaterol + tiotropium	563	0.313 (0.010)	0.117 (0.014)	<0.0001	0.090, 0.144
ANHELTO 2
Tiotropium + placebo	566	0.191 (0.010)
Olodaterol + tiotropium	563	0.297 (0.010)	0.106 (0.014)	<0.0001	0.078, 0.135
Trough FEV1
ANHELTO 1
Tiotropium + placebo	551	0.133 (0.009)
Olodaterol + tiotropium	548	0.195 (0.009)	0.062 (0.013)	<0.0001	0.037, 0.088
ANHELTO 2
Tiotropium + placebo	555	0.135 (0.009)
Olodaterol + tiotropium	550	0.175 (0.009)	0.040 (0.013)	0.0029	0.014, 0.065

Abbreviations: FEV₁, forced expiratory volume in 1 second; AUC_0–3, area under the curve from 0–3 hours; SE, standard error; CI, confidence interval.