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. Author manuscript; available in PMC: 2015 Oct 9.
Published in final edited form as: Cell. 2014 Oct 9;159(2):295–305. doi: 10.1016/j.cell.2014.09.020

Figure 1. Expression of the endogenous Oxtr gene in new bacTRAP transgenic lines (Nek7, Cort, Dlx1, Htr3a) targeting cortical interneuron populations.

Figure 1

(A) DAB immunohistochemistry (IHC) with anti-EGFP antibody on each mouse line in the medial prefrontal cortex (mPFC) reveals a unique and different pattern of expression for the EGFP-L10a transgene. (B) Summary of immunofluorescence studies using anti-EGFP and anti-PVALB, anti-SST, or anti-VIP antibody for each line. The Y-axis is the percentage of specific neuronal markers (Pvalb, Sst, Vip) that is also positive for EGFP. Error bars represent standard error of the mean (SEM). (C) Enrichment of Oxtr mRNA is observed in TRAP profiling data collected from Cort and Dlx1 interneurons, but not Nek7 RNA or Htr3a RNA. Error bars represent standard deviation (SD). (D) Diagram indicating that the Oxtr mRNA is present in a novel population of Sst expressing cortical interneurons.

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