Table 2. Unconjugated BPA (uBPA) and glucuronidated BPA (BPA-G) pharmacokinetic parameters for 4 male and 2 female subjects who held thermal receipt paper and ate French fries after using hand sanitizer (shown in Figure 5-A).
Analyte | Parameter | Male | Female | All |
Serum uBPA | Baseline (ng/ml) | 0.06±0.04 | 0.57±0.28 | 0.23±0.15 |
Cmax (ng/ml) | 5.66±1.25 | 10.24±0.77 | 7.19±1.26 | |
Maximum increase (ng/ml) | 5.60±1.24 | 9.66±0.37 | 6.95±1.17 | |
Range of increase (ng/ml) | 3.96–9.28 | 9.29–10.03 | 3.96–10.03 | |
Tmax (min) | 60.00±12.25 | 15.00±0.00 | 45.00±12.25 | |
Range of Tmax | 30.00–90.00 | 15.00 | 15.00–90.00 | |
Average AUC (0–90 min) (ng/ml) | 3.92±1.08 | 3.85±0.04 | 3.90±0.75 | |
Serum BPA-G | Baseline (ng/ml) | 0.60±0.10 | 2.95±0.91 | 1.38±0.55 |
Cmax (ng/ml) | 1.49±0.39 | 7.74±1.75 | 3.57±1.42 | |
Maximum increase (ng/ml) | 0.89±0.36 | 4.79±0.85 | 2.19±0.88 | |
Range of increase (ng/ml) | 0.09–1.58 | 3.94–5.63 | 0.09–5.63 | |
Tmax (min) | 75.00±8.66 | 75.00±15.00 | 75.00±6.71 | |
Range of Tmax | 60.00–90.00 | 60.00–90.00 | 60.00–90.00 | |
Average AUC (0–90 min) (ng/ml) | 1.05±0.21 | 6.48±1.93 | 2.86±1.25 | |
BPA-G/uBPA AUC (0–90 min) (ng/mL) | 0.35±0.12 | 1.82±0.30 | 0.84±0.33 | |
Urine Total BPA | Baseline (ng/ml) | 0.15±0.04 | 1.10±0.58 | 0.46±0.24 |
Baseline (µg/g creatinine) | 0.20±0.09 | 1.22±0.24 | 0.54±0.19 | |
90 min (ng/ml) | 23.36±6.66 | 10.62±3.16 | 19.11±4.32 | |
90 min (µg/g creatinine) | 18.20±5.33 | 40.93±22.56 | 25.77±8.56 |
For these subjects blood was collected from the arm draining the hand that remained contaminated with BPA throughout the 90-min period of blood collection. Urine total BPA at baseline and at 90 min are presented as both actual concentration (ng/ml) and creatinine adjusted (µg BPA/g creatinine) values.
For the one female (Female #3; Figure 5-B) who had very high baseline serum uBPA (data not included in this table), the average serum AUC (0–90) values for uBPA and BPA-G were 6.05 and 4.49 ng/ml, respectively, and urine total BPA levels at baseline and at 90 min were 0.41 and 41.41-µg/g creatinine, respectively.