Table 3. Unconjugated BPA (uBPA) and glucuronidated BPA (BPA-G) pharmacokinetic parameters for one male and two female subjects who held thermal receipt paper and ate French fries after using hand sanitizer (shown in Figure 5-C).
Analyte | Parameter | Male | Female | All |
Serum uBPA | Baseline (ng/ml) | 0.06 | 0.53±0.30 | 0.37±0.24 |
Cmax (ng/ml) | 0.42 | 5.44±0.42 | 3.77±1.69 | |
Maximum increase (ng/ml) | 0.37 | 4.91±0.13 | 3.40±1.53 | |
Range of increase (ng/ml) | 0.37 | 4.80–5.03 | 0.37–5.03 | |
Tmax (min) | 60.00 | 22.50±7.50 | 35.00±13.23 | |
Range of Tmax | 60.00 | 15.00–30.00 | 15.00–60.00 | |
Average AUC (0–90 min) (ng/ml) | 0.15 | 3.47±0.06 | 2.36±1.11 | |
Serum BPA-G | Baseline (ng/ml) | 0.38 | 1.22±0.36 | 0.94±0.35 |
Cmax (ng/ml) | 2.47 | 2.69±0.65 | 2.62±0.39 | |
Maximum increase (ng/ml) | 2.09 | 1.47±0.30 | 1.68±0.27 | |
Range of increase (ng/ml) | 2.09 | 1.18–1.77 | 1.18–2.09 | |
Tmax (min) | 90.00 | 60.00 | 70.00±10.00 | |
Range of Tmax | 90.00 | 60.00 | 60.00–90.00 | |
Average AUC (0–90 min) (ng/ml) | 1.65 | 1.87±0.38 | 1.80±0.23 | |
BPA-G/uBPA AUC (0–90 min) (ng/mL) | 11.00 | 0.54±0.12 | 4.03±3.49 | |
Urine Total BPA | Baseline (ng/ml) | 1.92 | 0.38±0.15 | 0.89±0.52 |
Baseline (µg/g creatinine) | 1.17 | 0.21±0.08 | 0.53±0.40 | |
90 min (ng/ml) | 27.86 | 29.34±0.35 | 28.85±0.54 | |
90 min (µg/g creatinine) | 27.35 | 14.11±1.16 | 18.53±4.46 |
For these subjects mixed systemic blood was collected from the uncontaminated arm over the 90 min after BPA exposure. Urine total BPA at baseline and at 90 min are presented as both actual concentration (ng/ml) and creatinine adjusted (µg/g creatinine) values.