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. Author manuscript; available in PMC: 2014 Oct 22.
Published in final edited form as: Subcell Biochem. 2014;85:337–358. doi: 10.1007/978-94-017-9211-0_18

Figure 3. p53 plays an important role in adaptation to metabolic derangements.

Figure 3

A shortage in metabolites such as glucose, glutamine and serine activate p53 which tune up metabolism to suppress undesired anabolic processes via the inhibition of mTORC1, stimulate ATP production via mitochondrial respiration rather than glycolysis, and use alternative fatty acid oxidation as other sources of ATP production. Dysregulation of these processes due to p53 inactivation in cancer cells can be beneficial for tumor growth.