FIGURE 2.
Autologous islet damage and the impact of NFκB inhibitors. The plasma levels of C-peptide (A), proinsulin (B), and thrombin-antithrombin (TAT) (C) in an autologous islet tube model are shown. Solid line (black circle), solid line (open circle), and dotted lines show the control, withaferin A (WA), and CAY10512 (CAY) groups, respectively. Symbols indicate the P value compared to baseline within each group of control*, WA‡ or CAY# and the significance levels: *P<0.05 and **<0.01. Also, the symbols indicate the P value when compared between the control and WA§ or CAY† groups. Data express average ± SE based on 3 independent experiments. Repeated-measurement two-way ANOVA with Dunnett’s multiple comparison test was performed for statistical evaluation.