Table 2. Associations between SNPs of MTHFR, MTR, MTRR, DNMT1, and ALDH2 genes and cancers of the esophagus, stomach, and liver.
| Esophageal Cancer | Stomach Cancer | Liver Cancer | |||||||||||||
| Ca/Co | SBOR1 (95% posterior limit) | One-sidedP * | SBOR2 (95% posterior limit) | One-sidedP * | Ca/Co | SBOR1 (95% posterior limit) | One-sided P * | SBOR2 (95% posterior limit) | One- sided P * | Ca/Co | SBOR1 (95% posterior limit) | One- sided P * | SBOR2 (95% posterior limit) | One- sided P * | |
| MTHFR | |||||||||||||||
| rs1801133 | |||||||||||||||
| CC | 65/135 | 1.00 | 1.00 | 50/135 | 1.00 | 1.00 | 50/135 | 1.00 | 1.00 | ||||||
| CT | 105/199 | 1.15 (0.79, 1.65) | 0.24 | 1.19 (0.80, 1.77) | 0.20 | 106/199 | 1.38 (0.94, 2.02) | 0.050 | 1.53 (1.00, 2.33) | 0.024 | 114/199 | 1.46 (1.00, 2.13) | 0.026 | 1.57 (1.02, 2.42) | 0.021 |
| TT | 32/57 | 1.13 (0.69, 1.86) | 0.32 | 1.35 (0.78, 2.32) | 0.14 | 38/57 | 1.66 (1.02, 2.71) | 0.021 | 2.26 (1.30, 3.91) | 0.002 | 30/57 | 1.31(0.78, 2.19) | 0.15 | 1.17 (0.64, 2.12) | 0.31 |
| P trend † | 0.50 | 0.21 | 0.021 | 0.001 | 0.12 | 0.24 | |||||||||
| Dominant | 1.15 (0.81, 1.64) | 0.22 | 1.25 (0.85, 1.84) | 0.13 | 1.49 (1.03, 2.16) | 0.018 | 1.79 (1.18, 2.71) | 0.003 | 1.46 (1.00, 2.12) | 0.024 | 1.51 (0.98, 2.32) | 0.029 | |||
| Recessive | 1.05 (0.67, 1.66) | 0.41 | 1.23 (0.74, 2.03) | 0.21 | 1.38 (0.90, 2.14) | 0.072 | 1.78 (1.09, 2.91) | 0.011 | 1.05 (0.66, 1.67) | 0.41 | 0.91 (0.53, 1.56) | 0.37 | |||
| MTR | |||||||||||||||
| rs1805087 | |||||||||||||||
| A/A | 161/310 | 1.00 | 1.00 | 142/310 | 1.00 | 1.00 | 149/310 | 1.00 | 1.00 | ||||||
| A/G | 35/76 | 0.90 (0.58, 1.37) | 0.31 | 0.79 (0.50, 1.27) | 0.17 | 46/76 | 1.31 (0.87, 1.96) | 0.096 | 1.16 (0.74, 1.83) | 0.26 | 40/76 | 1.03 (0.68, 1.56) | 0.45 | 0.92 (0.57, 1.47) | 0.36 |
| G/G | 4/0 | – | – | 1/0 | – | – | 1/0 | – | – | ||||||
| Dominant | 1.01 (0.66, 1.52) | 0.49 | 0.90 (0.57, 1.42) | 0.32 | 1.34 (0.90, 2.00) | 0.078 | 1.19 (0.76, 1.87) | 0.22 | 1.05 (0.69, 1.59) | 0.41 | 0.93 (0.58, 1.49) | 0.38 | |||
| MTRR | |||||||||||||||
| rs1532268 | |||||||||||||||
| C/C | 145/283 | 1.00 | 1.00 | 144/283 | 1.00 | 1.00 | 149/283 | 1.00 | 1.00 | ||||||
| C/T | 47/94 | 0.99 (0.67, 1.46) | 0.47 | 1.16 (0.76, 1.78) | 0.25 | 44/94 | 0.96 (0.65, 1.43) | 0.42 | 0.98 (0.63, 1.53) | 0.47 | 39/94 | 0.77 (0.51, 1.15) | 0.10 | 0.83 (0.52, 1.32) | 0.21 |
| T/T | 11/11 | 1.80 (0.86, 3.80) | 0.060 | 1.96 (0.89, 4.31) | 0.047 | 5/11 | 1.08 (0.45, 2.56) | 0.43 | 1.05 (0.43, 2.57) | 0.46 | 4/11 | 0.75 (0.31, 1.82) | 0.27 | 1.09 (0.42, 2.82) | 0.43 |
| P trend † | 0.27 | 0.070 | 0.98 | 0.97 | 0.14 | 0.61 | |||||||||
| Dominant | 1.11 (0.77, 1.61) | 0.29 | 1.32 (0.88, 1.98) | 0.089 | 0.98 (0.67, 1.44) | 0.45 | 1.00 (0.65, 1.52) | 0.49 | 0.75 (0.50, 1.11) | 0.075 | 0.85 (0.54, 1.34) | 0.25 | |||
| Recessive | 1.81 (0.86, 3.80) | 0.059 | 1.91 (0.87, 4.19) | 0.052 | 1.09 (0.46, 2.58) | 0.43 | 1.06 (0.43, 2.57) | 0.45 | 0.78 (0.33, 1.89) | 0.30 | 1.12 (0.43, 2.90) | 0.41 | |||
| rs1801394 | |||||||||||||||
| A/A | 117/204 | 1.00 | 1.00 | 119/204 | 1.00 | 1.00 | 114/204 | 1.00 | 1.00 | ||||||
| A/G | 74/149 | 0.88 (0.62, 1.25) | 0.24 | 0.92 (0.63, 1.35) | 0.34 | 63/149 | 0.75 (0.53, 1.08) | 0.063 | 0.74 (0.49, 1.11) | 0.070 | 64/149 | 0.78 (0.54, 1.12) | 0.092 | 0.74 (0.49, 1.12) | 0.078 |
| G/G | 10/25 | 0.81 (0.42, 1.59) | 0.27 | 0.95 (0.47, 1.93) | 0.44 | 9/25 | 0.76 (0.38, 1.50) | 0.21 | 0.77 (0.37, 1.60) | 0.24 | 13/25 | 0.93 (0.49, 1.75) | 0.41 | 1.39 (0.70, 2.78) | 0.17 |
| P trend † | 0.36 | 0.70 | 0.10 | 0.13 | 0.30 | 0.87 | |||||||||
| Dominant | 0.86 (0.61, 1.21) | 0.20 | 0.92 (0.64, 1.34) | 0.33 | 0.74 (0.52, 1.05) | 0.046 | 0.73 (0.49, 1.07) | 0.055 | 0.80 (0.56, 1.13) | 0.10 | 0.83 (0.56, 1.24) | 0.19 | |||
| Recessive | 0.85 (0.44, 1.64) | 0.31 | 0.97 (0.48, 1.96) | 0.47 | 0.82 (0.41, 1.62) | 0.29 | 0.84 (0.41, 1.74) | 0.32 | 1.00 (0.54, 1.88) | 0.50 | 1.53 (0.78, 3.03) | 0.11 | |||
| DNMT1 | |||||||||||||||
| rs2228612 | |||||||||||||||
| A/A | 52/100 | 1.00 | 1.00 | 43/100 | 1.00 | 1.00 | 48/100 | 1.00 | 1.00 | ||||||
| A/G | 56/200 | 0.58 (0.38, 0.88) | 0.006 | 0.52 (0.33, 0.82) | 0.003 | 72/200 | 0.84 (0.55, 1.28) | 0.21 | 0.82 (0.51, 1.31) | 0.20 | 74/200 | 0.79 (0.52, 1.19) | 0.13 | 0.79 (0.49, 1.28) | 0.17 |
| G/G | 29/57 | 1.03 (0.61, 1.73) | 0.46 | 0.96 (0.55, 1.68) | 0.44 | 28/57 | 1.11 (0.65, 1.89) | 0.36 | 1.12 (0.62, 2.04) | 0.35 | 36/57 | 1.33 (0.80, 2.22) | 0.13 | 1.35 (0.76, 2.42) | 0.15 |
| P trend † | 0.57 | 0.37 | 0.88 | 0.88 | 0.42 | 0.42 | |||||||||
| Dominant | 0.67 (0.45, 1.00) | 0.026 | 0.60 (0.39, 0.94) | 0.012 | 0.90 (0.59, 1.36) | 0.31 | 0.89 (0.56, 1.41) | 0.31 | 0.92 (0.62, 1.37) | 0.34 | 0.93 (0.58, 1.50) | 0.39 | |||
| Recessive | 1.38 (0.86, 2.21) | 0.092 | 1.35 (0.81, 2.25) | 0.13 | 1.22 (0.76, 1.97) | 0.20 | 1.26 (0.74, 2.15) | 0.20 | 1.53 (0.97, 2.40) | 0.033 | 1.54 (0.92, 2.59) | 0.051 | |||
| ALDH2 | |||||||||||||||
| rs671 | |||||||||||||||
| G/G | 118/213 | 1.00 | 1.00 | 108/213 | 1.00 | 1.00 | 109/213 | 1.00 | 1.00 | ||||||
| A/G | 60/160 | 0.70 (0.49, 1.01) | 0.029 | 0.76 (0.51, 1.13) | 0.088 | 76/160 | 0.97 (0.68, 1.38) | 0.44 | 1.06 (0.71, 1.57) | 0.39 | 74/160 | 0.91 (0.64, 1.30) | 0.31 | 1.05 (0.70, 1.58) | 0.41 |
| A/A | 25/20 | 1.97 (1.11, 3.49) | 0.010 | 1.61 (0.86, 3.00) | 0.066 | 12/20 | 1.13 (0.58, 2.21) | 0.36 | 0.99 (0.48, 2.03) | 0.49 | 10/20 | 1.03 (0.51, 2.06) | 0.47 | 0.96 (0.45, 2.06) | 0.46 |
| P trend † | 0.49 | 0.67 | 0.88 | 0.88 | 0.77 | 0.94 | |||||||||
| Dominant | 0.88 (0.63, 1.24) | 0.24 | 0.90 (0.62, 1.31) | 0.29 | 1.00 (0.71, 1.40) | 0.49 | 1.05 (0.71, 1.54) | 0.41 | 0.93 (0.66, 1.31) | 0.33 | 1.04 (0.70, 1.54) | 0.43 | |||
| Recessive | 2.20 (1.25, 3.86) | 0.003 | 1.76 (0.96, 3.24) | 0.035 | 1.14 (0.59, 2.21) | 0.35 | 0.97 (0.48, 1.97) | 0.47 | 1.06 (0.53, 2.10) | 0.44 | 0.95 (0.45, 2.01) | 0.44 | |||
| rs2238151 | |||||||||||||||
| C/C | 173/293 | 1.00 | 1.00 | 151/293 | 1.00 | 1.00 | 166/293 | 1.00 | 1.00 | ||||||
| C/T | 11/34 | 0.66 (0.35, 1.22) | 0.093 | 0.66 (0.34, 1.29) | 0.11 | 18/34 | 1.08 (0.61, 1.89) | 0.40 | 1.21 (0.65, 2.23) | 0.28 | 7/34 | 0.44 (0.22, 0.87) | 0.009 | 0.51 (0.23, 1.11) | 0.045 |
| T/T | 0/1 | – | – | 0/1 | – | – | 1/1 | 1.15 (0.33, 4.03) | 0.41 | 1.43 (0.39, 5.33) | 0.30 | ||||
| P trend † | – | – | – | – | 0.045 | 0.29 | |||||||||
| Dominant | 0.64 (0.35, 1.19) | 0.079 | 0.65 (0.33, 1.28) | 0.11 | 1.05 (0.60, 1.83) | 0.43 | 1.20 (0.65, 2.21) | 0.29 | 0.47 (0.24, 0.92) | 0.013 | 0.58 (0.27, 1.25) | 0.082 | |||
| Recessive | – | – | – | – | 1.16 (0.33, 4.07) | 0.41 | 1.44 (0.39, 5.37) | 0.29 | |||||||
| rs886205 | |||||||||||||||
| G/G | 173/315 | 1.00 | 1.00 | 150/315 | 1.00 | 1.00 | 149/315 | 1.00 | 1.00 | ||||||
| A/G | 29/69 | 0.81 (0.51, 1.26) | 0.17 | 0.78 (0.48, 1.28) | 0.17 | 41/69 | 1.23 (0.81, 1.87) | 0.17 | 1.47 (0.92, 2.34) | 0.054 | 40/69 | 1.19 (0.78, 1.81) | 0.21 | 1.38 (0.85, 2.24) | 0.096 |
| A/A | 2/4 | 1.07 (0.36, 3.18) | 0.45 | 1.00 (0.33, 3.08) | 0.50 | 2/4 | 1.10 (0.37, 3.30) | 0.43 | 1.18 (0.39, 3.65) | 0.38 | 2/4 | 1.00 (0.34, 2.96) | 0.50 | 1.27 (0.40, 4.10) | 0.34 |
| P trend † | 0.45 | 0.39 | 0.32 | 0.098 | 0.47 | 0.14 | |||||||||
| Dominant | 0.82 (0.53, 1.28) | 0.19 | 0.79 (0.49, 1.29) | 0.17 | 1.23 (0.82, 1.86) | 0.16 | 1.48 (0.93, 2.34) | 0.047 | 1.18 (0.78, 1.79) | 0.22 | 1.41 (0.88, 2.28) | 0.076 | |||
| Recessive | 1.08 (0.36, 3.23) | 0.44 | 1.02 (0.33, 3.13) | 0.49 | 1.08 (0.36, 3.24) | 0.44 | 1.16 (0.38, 3.55) | 0.40 | 0.98 (0.33, 2.92) | 0.49 | 1.25 (0.39, 4.03) | 0.35 | |||
1
: Semi-Bayes odds ratio (SBOR) adjusted for age (5-year categories and deviation from stratum mean) and sex.
2
: SBOR further adjusted for residency (city, rural), alcohol drinking frequency, smoking pack-years, BMI, education, H. pylori infection (in stomach cancer analyses), HBsAg (in liver cancer analyses), and plasma AFB1 levels (in liver cancer analyses), based on the assumption that genotype did not affect any of these variables.
*: One-sided semi-Bayes P-values; the posterior probability that the point estimate is on the wrong side of the null [26], [27].
†
: P-value from Chi-Square test for trend.