Table 4. Association between polygenetic risk score and cancers of the esophagus, stomach, and liver^¶.

Polygenetic risk score (8 SNPs)	Esophageal cancer			Stomach cancer			Liver cancer
	Ca/Co	SBOR†	One-sided P *	Ca/Co	SBOR†	One-sided P *	Ca/Co	SBOR†	One-sided P *
Equal-spaced categories
Lowest	20/65	1.00		37/131	1.00		27/64	1.00
Middle	65/165	1.21 (0.70, 2.08)	0.25	74/123	2.07 (1.28, 3.35)	0.001	88/194	0.95 (0.55, 1.64)	0.43
Highest	41/57	2.06 (1.13, 3.77)	0.010	14/33	1.55 (0.77, 3.11)	0.11	27/29	2.09 (1.05, 4.17)	0.019
Continuous (1 unit increase in PRS)		2.13 (1.23, 3.69)	0.004		2.37 (1.34, 4.19)	0.002		2.17 (1.11, 4.25)	0.012

^†: Semi-Bayes odds ratio (SBOR) adjusted for age (5-year categories and deviation from stratum mean), sex, residency (city, rural), alcohol drinking frequency, smoking pack-years, BMI, education, H. pylori infection (in stomach cancer analyses), HBsAg (in liver cancer analyses), and plasma AFB1 levels (in liver cancer analyses), based on the assumption that genotype did not affect any of these variables.

*: One-sided semi-Bayes P-values; the posterior probability that the point estimate is on the wrong side of the null [26], [27].

^¶: Polygenetic risk score (PRS) was calculated only among subjects with complete data on all 8 SNPs.