Figure 3. Awake training increased plasma cortisol concentrations in untrained animals, but not in trained animals.

Plasma cortisol concentrations measured from the animals (n = 8) at prior- and post-90-minute training session during the Phase 1b period. Results indicate that, at the end of training session cortisol levels are significantly elevated in untrained/control animals (n = 6), while no significant change was observed in habituated animals (paired t-test, **p<0.01). The dash lines highlight the range of normal cortisol concentration observed in cynomolgus monkeys (276 nmol/L to 1104 nmol/L) [52].