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. 2014 Oct 22;9(10):e110467. doi: 10.1371/journal.pone.0110467

Figure 2. Fluoxetine uptake and metabolism in fathead minnow following a 28-d study.

Figure 2

A) Relationship between measured (red line; mean ± SD; n = 20) and predicted (dashed line) plasma concentrations of fluoxetine, based on concentrations quantified in the water. The predicted plasma concentrations were generated by using the Fish Plasma Model [18]. B) Relationship between measured plasma concentrations of fluoxetine (red line; mean ± SD; n = 20) and norfluoxetine:fluoxetine ratio (grey line, mean ± SD; n = 20). The change in the slope of the plasma concentration curve corresponds to the decrease of the norfluoxetine:fluoxetine ratio, indicating inhibitory and/or saturation effects on the metabolic enzymes that convert fluoxetine into norfluoxetine. C) Relationship between measured plasma concentrations of fluoxetine in fish plasma (mean ± SD; n = 20) and Human Therapeutic Plasma Concentration range (grey area, 91–302 ng/mL). D) Relationship between measured plasma concentrations of norfluoxetine in fish plasma (mean ± SD; n = 20) and Human Therapeutic Plasma Concentration range (grey area, 72–258 ng/mL).