Table 2.
Drug (s) | Antiproteinuric | Preserve GFR | Diabetes type |
---|---|---|---|
ACE inhibitor | ++ | ++ | Type 1 and 2 |
ARB | ++ | ++ | Type 2 |
ACE inhibitor plus ARB | +++ | − | Type 1 and 2 |
Aldosterone antagonist | + | ? | Type 2 |
Aldosterone antagonist plus ACE inhibitor or ARB | +++ | ? | Type 1 and 2 |
Renin inhibitor | ++ | ? | Type 2 |
Renin inhibitor plus ACE inhibitor or ARB | +++ | − | Type 2 |
Non-dihydropyridine CCB | + | ? | Type 2 |
Non-dihydropyridine CCB plus ACE inhibitor or ARB | ++ | ? | Type 2 |
Dihydropyridine CCB | − | − | Type 2 |
Allopurinol | ? | ? | ? |
Statin | + | ? | Type 2 |
Vitamin D | + | ? | Type 2 |
Notes: + data exist to indicate benefit; − data exist to indicate lack of benefit or harm; ? insufficient data for conclusion, possible benefit. The number of + indicates a semiquantitative scale of beneficial effect.
Abbreviations: ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; GFR, glomerular filtration rate.