Table 1. Characteristics of the patients and methylation of HBV cccDNA in human liver sample.

Patient	Age (years)	Gender	HBeAg	HBeAb	genotype	Serum HBV DNA log10 copies/ml	Serum HBsAg log10 IU/ml	Knodell Fibrosis stage	Methylation density (%)
									CpG Island I	CpG Island II	CpG Island III
1	26	M	+	-	B	8.26	5.28	S2	0 (11)	0 (7)	11.11 (9)
2	42	M	+	-	B	8.42	3.51	S2	0 (8)	ND	0 (6)
3	26	M	+	-	B	8.08	4.24	S2-3	0 (12)	ND	ND
4	34	M	+	-	B	6.69	4.54	S2	0 (8)	20 (10)	12.5 (8)
5	34	M	+	-	B	7.85	5.10	S1	0 (10)	21.43 (14)	5 (20)
6	28	F	+	-	B	9.96	4.56	S2	8.33 (12)	16.67 (12)	22.22 (9)
7	51	M	+	-	B	7.37	4.76	S0	ND	11.11 (9)	ND
8	26	F	+	-	B	8.00	4.63	S1	0 (9)	14.29 (7)	0 (13)
9	40	M	+	-	C	7.00	3.84	S3	0 (19)	27.27 (11)	0 (18)
10	41	M	+	-	C	6.58	3.86	S3	0 (6)	ND	25 (4)
11	44	M	+	-	C	7.26	4.44	S1-2	0 (12)	ND	0 (6)
12	46	M	+	-	C	7.36	4.95	S1	0 (12)	36.36 (11)	0 (8)
13	64	F	+	-	C	7.70	4.70	S1	0 (15)	36.36 (11)	14.29 (7)
14	53	M	+	-	C	7.45	4.13	S2-3	7.69 (13)	ND	ND
15	42	M	-	+	B	4.80	1.96	S2	0 (13)	ND	ND
16	38	M	-	+	B	5.52	3.17	S1	0 (14)	0 (14)	0 (21)
17	36	M	-	+	B	6.20	2.95	S1	0 (14)	0 (8)	35.3 (17)
18	53	M	-	+	B	3.91	2.61	S2	7.14 (14)	33.33 (12)	35.71 (14)
19	35	M	-	+	B	5.56	3.10	S2	23.08 (13)	50 (12)	15.38 (13)
20	31	F	-	+	B	4.52	3.47	S1	0 (12)	18.18 (11)	14.29 (7)
21	57	F	-	+	B	4.57	3.35	S1	0 (12)	7.69 (13)	55.56 (9)
22	28	M	-	+	B	4.53	3.52	S2	ND	30 (10)	ND
23	52	F	-	+	C	4.74	3.68	S2	0 (13)	ND	0 (14)
24	36	M	-	+	C	3.64	3.25	S1	0 (16)	ND	0 (14)
25	62	M	-	+	C	4.26	ND	S2	0 (17)	46.15 (13)	71.43 (14)
26	43	M	-	+	C	3.00	3.25	S0	0 (11)	66.67 (9)	20 (5)
27	51	F	-	+	C	5.68	3.29	S3	0 (13)	58.33 (12)	33.33 (12)
28	32	F	+	-	C	8.57	3.57	S1	28.57 (7)	30 (10)	33.3 (3)
29	36	M	+	-	C	7.68	ND	S1	ND	12.5 (8)	50 (4)
30	33	F	+	-	C	8.42	2.89	S2	0 (7)	16.7 (6)	16.7 (6)

Numbers in brackets represent the number of total TA clones; ND: not detected.