Figure 4. Effects of propofol and gabazine on the large GABA_AR current during SD.

A&B Effects of propofol (200 µM) and gabazine (10 µM) on basal GABA transmission. Representative traces (A) and quantitative analysis (B) are shown. ****p<0.001, Control: n = 15, propofol n = 10 C&D Pharmacological characterization of the large GABA_AR current during SD. Gabazine nearly completely eliminated the early GABA_AR current, while propofol had little effect. Representative traces of early GABA_AR currents in control conditions as well as in the presences of gabazine and propofol, at the concentrations used in A&B. The SD onsets are defined by the onsets of extracellular DC shifts and are indicated by the arrows. D. Quantitative analysis of current amplitudes. Current amplitudes were determined from holding currents immediately before SD onset. Control: n = 9, gabazine: n = 8, propofol: n = 7, TTX: n = 7, **p<0.01 compared to others.