Table 3.
Population Characteristics of Participants Who Underwent Bridging
| Characteristic | Bridging Therapy at Least Once
|
||
|---|---|---|---|
| Yes (n=431) | No (n=4261) | P Value | |
| Age, y, median (25th, 75th percentiles) | 74 (68, 78) | 73 (65, 78) | 0.019 |
| Female, n (%) | 140 (32.5) | 1574 (36.9) | 0.067 |
| BMI, kg/m2, median (25th, 75th percentiles) | 28.8 (26.0, 32.1) | 28.4 (25.4, 32.3) | 0.22 |
| Blood pressure, systolic, mm Hg, median (25th, 75th percentiles) | 130 (120, 140) | 130 (120, 140) | 0.81 |
| Blood pressure, diastolic, mm Hg, median (25th, 75th percentiles) | 80 (70, 85) | 80 (70, 85) | 0.91 |
| Type of atrial fibrillation, n (%) | 0.44 | ||
| Persistent | 338 (78.4) | 3415 (80.1) | |
| Paroxysmal | 85 (19.7) | 794 (18.6) | |
| Newly diagnosed or new onset | 8 (1.9) | 52 (1.2) | |
| Prior chronic aspirin, n (%) | 124 (28.8) | 1603 (37.6) | 0.0003 |
| Prior vitamin K antagonist, n (%) | 340 (78.9) | 2690 (63.1) | <0.0001 |
| CHADS2 score, mean (SD) | 3.52 (0.93) | 3.40 (0.96) | 0.0094 |
| 1 | 0 (0.0) | 2 (<0.1) | |
| 2 | 41 (9.5) | 699 (16.4) | |
| 3 | 203 (47.1) | 1826 (42.9) | |
| 4 | 117 (27.1) | 1163 (27.3) | |
| 5 | 60 (13.9) | 489 (11.5) | |
| 6 | 10 (2.3) | 82 (1.9) | |
| History of stroke, TIA, embolism, n (%) | 226 (52.4) | 2132 (50.0) | 0.34 |
| History of CHF, n (%) | 261 (60.6) | 2665 (62.5) | 0.42 |
| History of hypertension, n (%) | 390 (90.5) | 3883 (91.1) | 0.66 |
| History of diabetes mellitus, n (%) | 207 (48.0) | 1748 (41.0) | 0.0049 |
| History of myocardial infarction, n (%) | 73 (16.9) | 801 (18.8) | 0.34 |
| Peripheral vascular disease, n (%) | 44 (10.2) | 259 (6.1) | 0.0009 |
| COPD, n (%) | 51 (11.8) | 522 (12.3) | 0.80 |
| Creatinine (Cockcroft-Gault equation), mL/min, median (25th, 75th percentiles) | 67 (53, 84) | 68 (53, 88) | 0.74 |
| Temporary interruptions, median (25th, 75th percentiles) | 1 (1, 2) | 1 (1, 2) | <0.0001 |
| 1 | 224 (52.0) | 2734 (64.2) | |
| 2 | 125 (29.0) | 993 (23.3) | |
| 3 | 59 (13.7) | 288 (6.8) | |
| 4 | 15 (3.5) | 138 (3.2) | |
| 5 | 4 (0.9) | 50 (1.2) | |
| 6–18 | 4 (0.9) | 58 (1.4) | |
BMI indicates body mass index; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; and TIA, transient ischemic attack.