On-treatment (safety population) major bleeding in key subgroups according to patient baseline characteristics. AF = atrial fibrillation; ASA = acetylsalicylic acid; BMI = body mass index; CHADS = congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack (TIA), or non–central nervous system thromboembolism (doubled); CI = confidence interval; CNS = central nervous system; CrCl = creatinine clearance; TIA = transient ischemic attack; VKA = vitamin K antagonists.