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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Anesthesiology. 2014 Nov;121(5):1010–1017. doi: 10.1097/ALN.0000000000000366

Figure 3.

Figure 3

Anesthesia of neonatal male, but not female, rats with propofol results in impaired prepulse inhibition (PPI) of the startle response. (A) Histogram showing PPI of startle in different treatment groups of male rats: negative control (n = 12), saline (n = 15), intralipid (n = 10), and propofol (n = 15). *P = 0.007 vs. negative control. PP5-PP15: prepulse intensities in decibels above background. (B) Histogram showing PPI of startle in different treatment groups of female rats: negative control (n = 12), saline (n = 15), intralipid (n = 12), and propofol (n = 16). (C) PPI of startle in male rats that received bumetanide (1.82 mg/kg, intraperitoneally) 15 min prior to induction of anesthesia with propofol for 5 h at postnatal days (P) 4, 5, or 6 (n = 12). The rats in the propofol group were the same as those in Fig. 3A. *P < 0.05 vs. propofol. (D) PPI of startle in male rats that received one injection of corticosterone (0.2 mg/kg, intraperitoneally) at P4, P5 or P6 (n = 10). The rats in the negative control and saline groups were the same as those in Fig. 3A.