Table 1.
Various signaling pathways involved in the dynamic balance among maintaining quiescence, activation, proliferation, differentiation, return to quiescence and self-renewal. Numbers refer to respective references.
| Signaling Pathway | SC function | References |
|---|---|---|
| Nitric oxide | Activation | 56,58 |
| Growth factors (IGF, FGF) | Activation | 57 |
| Notch | Maintenance of quiescence, proliferation, SC fate |
62,63,64,67 |
| Wnt | Differentiation, SC fate | 66,68,69 |
| MAPK | Self-renewal | 70,71 |
| Spry1 | Quiescence, return to quiescence after Self-renewal |
72 |
| Six1 | Self-renewal | 73 |
| Foxo3 | Return to quiescence after self- renewal |
76 |