Table 12.

Rofecoxib versus naproxen for myocardial infarction.

Study or subgroup	Rofecoxib		Naproxen		Weight	Peto OR, Fixed, 95% CI
	Events	Total	Events	Total
ADVANTAGE 2003 [Lisse et al. 2003]	5	2785	1	2772	22.3%	3.78 [0.76, 18.74]
Schnitzer et al. [2005]	0	104	1	121	3.7%	0.16 [0.00, 7.94]
VIGOR 2000 [Bombardier et al. 2000]	16	4047	4	4029	74.1%	3.31 [1.38, 7.97]
Total (95% CI)		6936		6922	100.00%	3.05 [1.43, 6.49]
Total events	21		6

Heterogeneity: chi squared = 2.30, degree of freedom = 2 (p = 0.32); I² = 13%. Test for overall effect: Z = 2.89 (p = 0.004).

CI, confidence interval; OR, odds ratio.