Table 13.

Rofecoxib versus naproxen for major vascular events.

Study or subgroup	Rofecoxib		Naproxen		Weight	Peto OR, Fixed, 95% CI
	Events	Total	Events	Total
ADVANTAGE 2003 [Lisse et al. 2003]	14	2785	7	2772	95.5%	1.94 [0.82, 4.58]
Schnitzer et al. [2005]	0	104	1	121	4.5%	0.16 [0.00, 7.94]
Total (95% CI)		2889		2893	100.00%	1.73 [0.75, 4.00]
Total events	14		8

Heterogeneity: chi squared = 1.51, degree of freedome = 1 (p = 0.22); I² = 34%. Test for overall effect: Z = 1.29 (p = 0.20).

CI, confidence interval; OR, odds ratio.