Figure 2.
Effect of chronic social defeat stress (CSDS) on apoptosis in the dentate gyrus (DG) of Ghsr-null and wild-type littermates. (a, b). Activated caspase 3-positive (AC3+) cell counts in the subgranular zone of the dorsal (a) and ventral (b) DG of CSDS-exposed or non-CSDS-exposed mice. Group sizes indicated. (c–f) Representative photomicrograph images of the ventral DG from each study group. (g–l) Magnified images of AC3+ cells. Legend in panel (a) pertains to panel (b). Scale bar in panel (d) (300 μm) pertains to panels (c–f), in panel (g) (50 μm) pertains to panels (g–i) and in panel (j) (75 μm) pertains to panels (j–l). *P < 0.05, comparing genotypes. #P < 0.05, ##P < 0.01, comparing treatment.