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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Mol Psychiatry. 2014 Apr 22;20(4):500–508. doi: 10.1038/mp.2014.34

Figure 3.

Figure 3

Effects of P7C3 on dentate gyrus (DG) cellular proliferation and apoptosis following chronic social defeat stress (CSDS). (a) Protocol schematic. (b–e) Bromodeoxyuridine-positive (BrdU+) and activated caspase 3-positive (AC3+) cell counts in the dorsal and ventral DG of CSDS-exposed and non-CSDS-exposed mice treated with P7C3 vs vehicle. Group sizes indicated. (f–k) Representative photomicrograph images of double-immunolabeled (BrdU and AC3) ventral DG sections. (l–q) Magnified images of immunoreactive cells (AC3+, leftward-facing arrow; BrdU+, rightward-facing arrow). Scale bar in panel (k) (100 μm) pertains to panels (f–k) and in panel (q) (25 μm) pertains to panels (l–q). *P < 0.05, **P < 0.01, ***P < 0.001, as compared with respective non-CSDS-exposed, vehicle-treated control group.