Fig 12. In the presence of InsP₃ agonist.

In the presence of InsP₃ producing agonist, activation of InsP₃R evoked cytosolic Ca²⁺ release from ER that are transmitted to the mitochondria (1). The mitochondrial Ca²⁺ refills ER (2). If inhibition of the mitochondrial Ca²⁺ uptake by Ru360, the transient Ca²⁺ will facilitate rate of CICR and RyR(3) to empty more of the ER Ca²⁺ stores and activated more CCE (4).