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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Metab Brain Dis. 2014 Apr 22;29(4):1083–1093. doi: 10.1007/s11011-014-9541-4

Figure 2. Inhibition of mitochondrial exporter by CGP37157 diminished CCE induced by CPA.

Figure 2

Blockade of mitochondrial Ca2+ exporter by CGP37157 diminished CCE. Fibroblasts were loaded with Fura 2AM for 60 min. After loading, the media were changed to calcium free BSS, and 3 min later the calcium measurements were initiated. CGP37157 (20, 40 μM), an inhibitor of the mitochondrial Na+/Ca2+ exchanger blocker was added after 1 min of basal [Ca2+]i measurements, and CPA (2 μM) was added after 5 min. After an additional 2 min, CaCl2 (final concentration of 2.5 mM) was added. The top panel shows the tracings taken from 45–133 cells. The bottom panel shows the integration of the [Ca2+]i peak over the 3 min interval after calcium addition. Data are means ± SEM (n=45–133 cells). Asterisks indicate values vary significantly (p<0.05) from the control group by ANOVA followed by Student Newman Keul’s test.