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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Cell Rep. 2014 Sep 15;8(6):1731–1740. doi: 10.1016/j.celrep.2014.08.030

Figure 2. P7C3-S243 Preserves Hippocampal Synaptic Transmission after Blast-Mediated TBI.

Figure 2

Treatment with P7C3-S243 rescued blast-injury-induced deficits in long-term potentiation (LTP) and paired-pulse facilitation (PPF) in the hippocampal CA1 Schaffer-collateral pathway. (A) LTP induced by 12 theta burst stimulation (TBS) is significantly decreased in animals that sustained blast-induced TBI 14 days prior to testing. (B) This deficit was not rescued by treatment with low dose P7C3-S243 (0.3 mg/kg/d) starting 24 hours after injury, but was rescued by treatment with higher doses of (C) 3 and (D) 30 mg/kg/d P7C3-S243. LTP 1 hour after 12 TBS is summarized by quantification of the initial slope in panel (E). (F) Blast-injury-induced PPF deficit of 50 ms inter-pulse interval was also rescued in animals treated with the two higher doses (3 and 30 mg/kg/d) of P7C3-S243. Data are represented as mean ± SEM. Statistics were determined by one-way ANOVA with Tukey’s post hoc test.