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. 2014 Oct 14;2:37. doi: 10.1186/s40425-014-0037-x

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© Pilones et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CD1d blockade enhances IFN-γ response by tumor-specific cells generated by RT + anti-CTLA-4 blockade. WT or iNKT^−/− mice were treated with local tumor radiotherapy in two fractions of 12 Gy given on days 13 and 14 post-tumor inoculation. Mice received anti-CTLA-4 mAb on days 15, 18 and 21. Some mice additionally received anti-CD1d mAb on days 3, 7 and 11 post tumor inoculation. Cells from tumor-draining lymph nodes were collected on day 23 and stimulated with feeder cells pre-loaded with irrelevant peptide pMCMV (open circles) or AH-1-A5 (filled circles). Secreted IFN-γ in the supernatant was measured 48 hours later. Each symbol represents an individual mouse. Bars indicate the mean ± SD of 5 mice/group. ^* p < 0.05, ^** p < 0.005, ^*** p < 0.0005.