Table 4.
Characteristics of cases and controls for replication study
| Cases | Controls | ||||||
|---|---|---|---|---|---|---|---|
| Original study (N = 3,315) N (%) | Raw data study (N = 3,458) N (%) | CDM study (N = 3,454) N (%) | Original study (N = 13,139) N (%) | Raw data study (N = 13,165) N (%) | CDM study (N = 13,159) N (%) | Sensitivity study (N = 12,891) N (%) | |
| Age (years) | |||||||
| <40 | 91 (2.8) | 67 (1.9) | 67 (1.9) | 367 (2.8) | 259 (2.0) | 260 (2.0) | 252 (2.0) |
| 40–49 | 417 (12.6) | 373 (10.8) | 373 (10.8) | 1,656 (12.6) | 1,441 (10.9) | 1,443 (11.0) | 1,423 (11.0) |
| 50–59 | 830 (25.0) | 876 (25.3) | 875 (25.3) | 3,314 (25.2) | 3,330 (25.3) | 3,326 (25.3) | 3,276 (25.4) |
| 60–69 | 1,227 (37.0) | 1,263 (36.5) | 1,261 (36.5) | 4,832 (36.8) | 4,836 (36.7) | 4,830 (36.7) | 4,732 (36.7) |
| 70–75 | 750 (22.6) | 879 (25.4) | 878 (25.4) | 2,970 (22.6) | 3,304 (25.1) | 3,300 (25.1) | 3,208 (24.9) |
| Male | 2,452 (74.0) | 2,546 (73.6) | 2,543 (73.6) | 9,715 (73.9) | 9,692 (73.6) | 9,685 (73.6) | 9,463 (73.4) |
| Female | 863 (26.0) | 912 (26.4) | 911 (26.4) | 3,424 (26.1) | 3,478 (26.4) | 3,474 (26.4) | 3,428 (26.6) |
| Smoking status | |||||||
| Non | 1,079 (32.6) | 924 (26.7) | 921 (26.7) | 6,204 (47.2) | 4,475 (34.0) | 4,510 (34.3) | 5,157 (40.0) |
| Current | 1,100 (33.2) | 963 (27.8) | 964 (27.9) | 2,574 (19.6) | 2,074 (15.7) | 2,112 (16.0) | 2,286 (17.7) |
| Ex | 376 (11.3) | 291 (8.4) | 290 (8.4) | 1,353 (10.3) | 904 (6.9) | 888 (6.7) | 1,069 (8.3) |
| Unknown | 760 (22.9) | 1,280 (37.0) | 1,279 (37.0) | 3,008 (22.9) | 5,717 (43.4) | 5,649 (42.9) | 4,379 (34.0) |
| Body mass index (kg/m2) | |||||||
| <25 | 885 (26.7) | 740 (21.4) | 738 (21.4) | 4,240 (32.3) | 2,753 (20.9) | 2,861 (21.7) | 3,216 (24.9) |
| 25–29 | 1,100 (33.2) | 798 (23.1) | 798 (23.1) | 4,004 (30.5) | 2,874 (21.8) | 2,892 (22.0) | 3,275 (25.4) |
| ≥30 | 387 (11.7) | 318 (9.2) | 318 (9.2) | 1,208 (9.2) | 905 (6.9) | 880 (6.7) | 1,021 (7.9) |
| Unknown | 943 (28.4) | 1,602 (46.3) | 1,600 (46.3) | 3,687 (28.0) | 6,638 (50.4) | 6,526 (49.6) | 5,379 (41.7) |