A transformation of the Clinical Practice Research Datalink (CPRD) into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) was performed

Quality assessments indicated that source code mappings, Read code domain classification, imputation algorithm for drug duration and special handling of lifestyle/clinical data were accurate and acceptable data loss occurred across CDM domains

A case–control replication study was performed on the CPRD raw data and the CPRD CDM and results between the raw data and CDM study agreed for conditions, demographics and lifestyle data. There was slight nonsteroidal anti-inflammatory drug exposure data loss caused by unmapped drugs