Table 1.
FID-based determination of DC50 values (µM) of dimeric diazofluorenes against polynucleotides of increasing GC content.
| polynucleotide (%GC content) |
C. perfringens (32%) |
Calf thymus (42%) |
M. lysodeiktius (75%) |
|---|---|---|---|
| (−)-lomaiviticin aglycon (9) | 14.4 | 7.47 | 9.98 |
| (2S,2′S)-lomaiviticin aglycon (10) | 56.2 | 40.7 | 63.2 |
| C-3/C-3′-dideoxylomaiviticin aglycon (12) | 18.6 | 19.8 | 59.7 |
| (−)-monomeric lomaiviticin aglycon (11) | >100 | >100 | >100 |
| (−)-kinamycin C (6) | >100 | >100 | >100 |
| C-3-deoxy-monomeric lomaiviticin aglycon (13) | >100 | >100 | >100 |