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. 2014 May 2;2:16. doi: 10.3389/fcell.2014.00016

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Copyright © 2014 Ikehara and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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This is a summary of this review. IBM-BMT increased insulin sensitivity by upregulating the expression of HO-1, AKT and AMPK, and improving T2DM. IBM-BMT also regulated the expression of inflammatory cytokines, controlled the balance between bone absorption and bone formation, and improved osteoporosis. Furthermore, IBM-BMT regulated the expression of HO-1, iNOS and IL-1β, resulting in improved cognitive ability.